Fear of Germs

Mysophobia

William A. Hammond coined mysophobia in 1879 while describing a case of obsessive-compulsive disorder, specifically repeated hand-washing. The word is now classified as a specific phobia, which leaves it in an odd position: it was made to describe a compulsion and it currently names a fear.

That is not a pedantic distinction. A specific phobia is treated by exposure, on the expectation that fear declines with repetition. A compulsion is maintained by the relief the ritual provides, and exposure without response prevention leaves the ritual intact. The same word covering both is a practical problem rather than a historical curiosity.

What the Greek mysos actually says

Mysos means uncleanness or pollution. The word contains no reference to microbes, bacteria or infection, and predates any germ theory the modern usage assumes.

The alternatives fix that at the cost of narrowing it: verminophobia, germophobia, germaphobia, bacillophobia and bacteriophobia each name a specific agent. Mysophobia is the broadest and the oldest, and it names a moral quality rather than a biological one, which is closer to how the fear actually behaves.

Which behaviours mysophobia generates

The behaviours are recognisable and the material lists them plainly:

  • excessive hand-washing, and several showers a day
  • sanitising hands after touching any unknown surface
  • wearing gloves and covering commonly used items
  • avoiding places likely to have a high presence of germs

Two items are heavier than the rest: a fear of physical contact even with people the person loves, and the avoidance of social interaction and public spaces.

The physical symptoms are those of anxiety, with brain fog, frequent crying and irritability listed alongside the usual lightheadedness, palpitations, sweating and shaking.

Why no prevalence figure exists

No formal evaluation of prevalence in the general population exists. What exists are associations: with other anxiety disorders, with obsessive-compulsive disorder in particular, and, from Bajwa, Chaudhry and Saeed, between pre-existing mental illness and higher rates of severe phobias including this one in women.

What the microbe studies found

Robinson, Cameron and Jorgensen found associations between microbe literacy and time spent in nature on the one hand, and positive attitudes toward microbes on the other. The suggestion that follows is that a lack of both may contribute to mysophobia.

They also argue that immune disorders may have become more common partly through insufficient exposure to normal household dirt in infancy. Set the two together and the same variable, ordinary contact with the microbial world, appears on both sides: reduced exposure may raise both immune disorder and fear of microbes.

The material adds that germophobia has likely become more prevalent recently, particularly with the COVID-19 pandemic, which is a plausible statement with no figure behind it.

Why the article ends with names

The article ends with a list of well-known people reputed to have or to have had mysophobia, mixing historical figures with living public ones. No source is attached to any individual claim, and this catalogue does not repeat unsourced statements about a named living person's health.

It is recorded here as a feature of the article because a reader will meet it, and because the list is doing something worth noticing: it is the article's only concrete content about who has this fear, in a piece that admits nobody has measured how many people do.

What the formal criteria require

As a specific phobia in DSM-5 terms, the diagnosis asks for a distinct association between germs or contamination and fear, immediate anxiety on exposure, a reaction unreasonable given the actual danger and the sociocultural context, intentional avoidance or endurance with significant distress, clinically significant impairment, persistence beyond six months, and no better explanation from another disorder.

The third of those is doing quiet work. A reaction has to be unreasonable given the sociocultural context, and the context moved substantially between 2019 and 2021. Hand sanitising after touching an unknown surface was a symptom in the list above and a public health instruction shortly afterwards.

Told apart

Often confused with Fear of Germs

Common questions

Questions about Mysophobia

Who coined the word and what were they describing?
William A. Hammond, in 1879, while describing a case of obsessive-compulsive disorder involving repeated hand-washing. The word is now classified as a specific phobia, so it was made for one condition and currently names another. That matters practically: a phobia is treated by exposure, while a compulsion needs response prevention as well.
Does mysophobia mean fear of germs?
Not according to the Greek. Mysos means uncleanness or pollution, with no reference to microbes, bacteria or infection, and the word predates germ theory. Germophobia, bacillophobia and verminophobia are the later and narrower terms that actually name an agent.
How many people have it?
Nobody has established that. No formal evaluation of its prevalence in the general population exists. What research there is concerns associations, including one from Bajwa, Chaudhry and Saeed between pre-existing mental illness and higher rates of severe phobias including this one in women.
Does knowing about microbes help?
Robinson, Cameron and Jorgensen found associations between microbe literacy, time spent in nature and positive attitudes toward microbes, and suggested that a lack of both may contribute to the fear. The same researchers argue that reduced exposure to ordinary household dirt in infancy may have raised rates of immune disorder, which puts the same variable on both sides.
Did the pandemic change what counts as excessive?
It changed the test. The diagnostic criteria require the reaction to be unreasonable given the actual danger and the sociocultural context, and the context moved. Sanitising hands after touching an unknown surface appears in the symptom list and was also public health advice within a couple of years of it.

Added 2026-08-23 · Revised 2026-08-26